Research & Evidence
Evidence, with the labels left on.
A cell model asks a different question from a human trial. Here is what can be referenced, what it supports and where the limits sit.
01 · Preclinical / intestinal-cell model
Phosphopeptides in the laboratory.
Feng & Mine, 2006
“Phosvitin phosphopeptides increase iron uptake in a Caco-2 cell monolayer model.” The study reported concentration-dependent iron uptake in a laboratory model using phosvitin phosphopeptides.
Research note: Feng & Mine · iron uptake in cellsWhat this supports
A rationale for studying processed phosphopeptides and iron availability under specified experimental conditions.
What it does not establish
Human absorption, ferritin response, long-term tolerability or the performance of Beyond Iron+.
02 · Preclinical / rodent model
Intact protein. A different result.
Ishikawa et al., 2007
“Egg yolk protein and egg yolk phosvitin inhibit calcium, magnesium, and iron absorptions in rats.” This study concerns intact egg-yolk components—not a clinical evaluation of processed phosphopeptides.
Research note: Ishikawa · intact phosvitin in ratsThe important distinction
Strong binding can impede availability. Results for intact phosvitin should not be applied directly to a phosphopeptide formulation, or vice versa.
Rodent findings inform a hypothesis; they are not a human outcome.
03 · Foundational ingredient work
The Ecovatec foundation.
Ecovatec contributes foundational ingredient science, processing and manufacturing know-how. This commercial context is distinct from the peer-reviewed studies above, which should not be read as clinical validation of an Ecovatec or Beyond finished product.
Product-specific methods, specifications and performance claims require supporting documentation and an appropriate study. We are not presenting unpublished supplier claims as independently verified outcomes.
04 · Preliminary human observations
Details under review.
Earlier preliminary observations have been discussed, but their protocol, participant data and source documentation are not currently verified for public reporting here. Numerical outcomes and cross-study performance comparisons are therefore withheld.
No verified completed human study of Beyond Iron+ is presented on this page. Any future report will identify the study population, formulation, dose, methods, results and limitations.
05 · Clinical context / not Beyond Iron+ evidence
Vitamin C: a useful distinction.
Li et al.’s 2020 randomized clinical trial included 440 adults with iron deficiency anemia. Iron alone and iron plus vitamin C produced equivalent hemoglobin responses in that setting. This is relevant to the claim that vitamin C is always necessary with iron; it is not a test of phosphopeptides or Beyond Iron+.
Research note: Li · iron with or without vitamin CBeyond Iron+ · Human study
Now comes the human part.
We are initiating the planning of a human study to investigate iron uptake, ferritin response, tolerability and adherence, according to the final protocol. Ethics approval and study authorization are not yet confirmed.
Interest only. Not recruitment or study enrollment.
How we read evidence
One result is not every claim.
Human efficacy claims should be supported by evidence relevant to the exact product, population and claimed outcome. We separate laboratory mechanisms, animal observations, clinical studies and future plans rather than treating them as interchangeable proof.
Research note: FTC · evidence behind health claimsBeyond research summaries
Read the question behind the citation.
Original reading notes, with the measured endpoint, the useful conclusion and the limits together. Each note keeps the publisher’s original a separate, optional next step.
Laboratory · intestinal-cell model
Research note: Feng & Mine · iron uptake in cellsAgency guidance · advertising substantiation
Research note: FTC · evidence behind health claimsAgency education · nutrition labeling
Research note: FDA · what Daily Value meansAuthoritative review · nutrition and clinical context
Research note: NIH ODS · iron in contextPreclinical · animal feeding study
Research note: Ishikawa · intact phosvitin in ratsHuman · randomized equivalence trial
Research note: Li · iron with or without vitamin C